Induction of olfactory neuroepithelial tumors in syrian hamsters by diethylnitrosamine
نویسندگان
چکیده
منابع مشابه
Induction of tumors in the Syrian hamster with diethylnitrosamine (N-nitrosodiethylamine).
Tumors of the liver, kidneys, and lungs have been induced in rats by the feeding of dimethyl nitrosamine (DMN) and diethylnitrosamine (DENA) (1, 11, 12, 18). Dontenwill et al. (3, 4) reported that squamous-cell carcinoma of the trachea and lung of Syrian hamsters followed ad ministration of DENA by each of three ap proaches—tube feeding, inhalation, and subcu taneous injection. They observed ...
متن کاملExperimental Animals and Induction of Brain Tumors. Newborn Syrian hamsters obtained from Engle's Labora
In vitro cultivation of medulloblastoma cells was success fully established from hamster brain tumors induced by simian adenovirus SA7. These tumor cells possess morpho logical features in cultures that are very similar to those of the original tumor. Both tubular and rosette growth pat terns were evident. At the ultrastructural level only small numbers of cytoplasmic organdies could be detecte...
متن کاملN,N'-dimethylnitrosourea-induced tumors in mice and Syrian hamsters.
Carcinogenic effect of N, N’-dimethylnitrosourea (DMNU) on mice and hamsters was studied. Repeated subcutaneous injections　of DMNU resulted in the induction of malignant lymphomas with an　incidence of 100 per cent in adult C3HjBifBjKi mice and induced　malignant tumors of　forestomach, mammary gland and uterus with a　high incidence in adult hamsters. Control ani...
متن کاملBiological characteristics of two transplantable pituitary tumors of Syrian hamsters.
appear to be common in the Syrian hamster. Among thirteen spontaneous tumors occurring in one series of a thousand hamsters of unspecified age, none were of pituitary origin (1). No pituitary tumors were reported among 226 animals autop sied at the end of a normal life span, although the majority of these old hamsters had both benign and malignant neoplasms which were frequently multiple (2). O...
متن کاملComparative carcinogenesis by nitrosomethylalkylamines in Syrian hamsters.
Six homologous nitrosomethyl-n-alkylamines, from n-propyl (C-3) to n-octyl (C-8), were administered by gavage to groups of 12 male and 12 female Syrian golden hamsters as solutions in corn oil:ethyl acetate (2:1). The solutions of C-8 to C-4 were equimolar; nitrosomethyl-n-butylamine (C-4) and nitrosomethyl-n-propylamine (C-3) were given at a lower concentration. Treatment with 0.2 ml of soluti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer
سال: 1964
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(196401)17:1<114::aid-cncr2820170115>3.0.co;2-q